Nianbai Fang, Ph.D.
Department of Pediatrics
Section of Developmental Nutrition
My research program is centered on characterizing bioactive phytochemicals in diets by analysis of their metabolites in the urine and serum of infants, and in tissues of animals. As a natural products chemist, I also contribute to the metabolomics program focusing on targeted and untargeted metabolome analysis (small molecules), which is an extremely important area for a wide-range of ACNC research programs. Our lab is particularly interested in identifying novel and known metabolites produced by the gastrointestinal microbiome. This is important since the microbiome is very responsive to nutrition and postnatal diet, playing a critical role in the function and health of the gut and other tissues of the body. The analytical studies are carried out using a QP2010 GC-MS (Shimadzu), API 2000 LC-MS/MS (Applied Biosystems), 4000Q-TRAP LC-MS (Applied Biosystems), Q Exactive LC-MS (Thermo Scientific) and Isotope-ratio mass spectrometry (IRMS) (Thermo Scientific). Another area of interest is a bioactivity-directed separation project aimed at identifying bioactive factors, using a mix of in vitro cell culture bioassay and analytical chemical methods. The long-term aim of our research is to promote health and prevent metabolic (e.g., obesity and diabetes) and inflammatory diseases.