Bone Structure & Histomorphometry
The Bone Structure & Histomorphometry Facility offers a comprehensive evaluation of gross skeletal and histological bone parameters for clinical and basic research studies. The laboratory has capabilities to assess bone mass (bone mineral density, content and strength) in both humans and animal models, and cellular changes (osteoblast and osteoclast numbers and bone formation rate) for assessing the effects of diet and lifestyle factors on bone remodeling in animal models during their development. We have two up-to-date Stratec XCT peripheral quantitative CT-scan (pQCT) systems (for human and animal studies respectively), dual-energy X-ray absorptiometry, and bone magnetic resonance imaging (MRI) systems. The facility is also equipped with dedicated OsteoMeasure™ Histomorphometry Systems (OsteoMetrics™, Inc.). The system is used by trained laboratory personnel to generate static and dynamic histomorphometric data based on ASBMR standardized nomenclature and formulae for studies examining the roles of diet, obesity and physical activity on bone health.