Animal Studies Core

Animal Studies Core

The ACNC Animal Studies Core assists investigators in conducting animal research for the advancement of human health. Our Core is a comprehensive, fully accredited research facility staffed by highly-skilled and certified associates. Utilizing cutting-edge technology, studies are held to specific controlled conditions regarding environment, diet, metabolism, and activity. The Core is home to specialized equipment and instruments that allow our team to monitor and collect scientific data specific to each study. A kitchen for customized diet preparation is available, as well. The Core has over 35 secure rooms monitored and strictly controlled for breeding, housing and study procedures. Staff are trained in all aspects of animal husbandry and health, surgery, glucose tolerance tests and hyperinsulinemic-euglycemic clamps, and other specialized techniques.

The facility is equipped to carry out detailed metabolic phenotyping under various conditions using a state-of-the-art Promethion Core monitoring system (Sable Systems) for assessments of food/water-intake, energy expenditure via indirect calorimetry (oxygen consumption and carbon dioxide release), and activity measurements. Additionally, a Comprehensive Laboratory Animal Monitoring System (CLAMS) to perform 24-h metabolic measurements is available. Metabolic studies can also be carried out in germ-free isolators. The Core also has facilities to assess whole animal body composition using X-ray computerized tomography (LaTheta CT, LCT-100 scanner) and nuclear magnetic resonance (Echo MRI), and to study bone using peripheral quantitative computerized tomography (pQCT).

A technician uses a CT scanner for non-invasive assessment of body composition.

A technician uses a pQCT scanner for non-invasive assessment of bone quality.

A technician prepares for a metabolic phenotyping run used to assess both energy intake and energy expenditure.

A staff of 5 highly skilled and certified employees maintain the animal core facility and conduct all studies.